• About Arestin®
  • The Arestin® Facts
  • Arestin® FAQ
  • How Does Arestin® Work
  • Tips After Treatment

About Arestin®

Arestin® (minocycline HCl 1mg) microspheres is a treatment for chronic periodontitis, an infection of the gums that can lead to tooth loss. Research has shown periodontitis may be linked to other serious diseases such as cardiovascular disease, osteoporosis, and diabetes. Microsphere technology enables extended release of the antibiotic minocycline to effectively kill the germs that cause periodontal disease.

The Arestin® Facts

Treatment with Arestin® (minocycline HCl 1mg) microspheres is fast, easy and doesn’t cause discomfort.Treating periodontal disease with Arestin and scaling and root planing will help you manage chronic periodontist more effectively than scaling and root planing alone. You’ll also be less likely to lose your teeth.

Patients treated with Arestin experience minimal side effects.

Arestin does not require bandages or stitches.Arestin is bioadhesive and bioresorbable. It will not leak, fall out, or leave anything to be removed by the dentist or hygienist in a follow-up visit.

Treating periodontitis with Arestin plus SRP can keep this chronic disease from progressing to the point where surgery is needed.

Arestin doesn’t require anesthesia because application is comfortable.

Arestin® FAQ

Who can benefit from Arestin® (minocycline HCl 1mg)?

Most patients with periodontal disease can benefit from Arestin. However, Arestin should not be used on children and pregnant or nursing women.

Is treatment with Arestin a new procedure?

The use of a locally administered antibiotic is not a new concept. For years, dentists have used antibiotics in conjunction with scaling and root planing treatments. However, Arestin, which was FDA-approved in February 2001, is the first locally-administered time released antibiotic encapsulated in microspheres to make Arestin a fast, easy treatment that doesn’t cause discomfort and has been shown to be more effective than SRP alone.

Does Arestin work?

Yes, Arestin plus scaling and root planing is an effective treatment for periodontal disease compared to scaling and root planing alone. Clinical studies show that patients who received a combined treatment of scaling and root planing and Arestin maintained healthier gums and pockets versus those who were treated with scaling and root planing alone.

How long does treatment with Arestin take?

In clinical trials, investigators were able to treat an average of 30 periodontal pockets, in less than ten minutes. That’s up to three sites in one minute! Treatment time for placement depends on the location and the number of periodontal pocket sites, but generally the procedure is fast, easy and comfortable.

Will I have to return to the dentist to have Arestin removed?

No. Arestin does not require bandages and won’t leak or fall out. It is naturally absorbed into the gums, leaving nothing that needs to be removed by your dentist.

Does treatment with Arestin hurt?

Treatment with Arestin is easy and doesn’t cause discomfort. There is no need for anesthesia, and that means no needles.

Are there any side effects?

In clinical studies, minimal side effects were reported. Those that were reported were similar to those in the placebo group. Arestin does not alter taste buds, cause teeth staining, or upset stomach.

How much does Arestin cost?

The cost of Arestin treatment will vary depending upon your treatment needs. After your dentist has evaluated your oral health and discussed the treatment options, he or she can provide you with an estimate of the cost. Keep in mind that treating your gum disease today is less costly and better for your health than waiting to treat symptoms at a more advanced stage.

When is Arestin Placed?

  • Inflammation and bleeding is usually present. 
  • Plaque and Calculus are present. 
  • After Scaling and Root Planing of the tooth. 
  • Plaque and Calculus are removed. 
  • Leaving a CLEAN tooth surface.
  • Now the site is ready for Arestin Placement

Where is Arestin Placed?

  • Arestin® microspheres are placed in the periodontal Pocket. 

  • The Microspheres carry the antibiotic minocycline. 

  • The mocrospheres are actively releasing the minocycline up to 14 days. 

  • The microsphere are completely resorbed on there own.

The Result of Arestin Use

  • Follow up visits will reveal no bleeding upon probing. 

  • No inflammation in most cases. 

  • No bleeding in most cases.

How Does Arestin® Work?

Arestin® (minocycline HCl 1mg) microspheres provides dental professionals with a fast and easy way to treat periodontal disease. Arestin uses microsphere technology that delivers minocycline, a potent but low-dose antibiotic that kills the bacteria that cause periodontal disease. Minocycline is placed painlessly under the gum, directly to the infected site 

If you could see them, these microspheres would look like tiny beads of many different sizes.However, they are smaller than a grain of sand and look like a yellow powder to the naked eye. Administered as a powder, the microspheres become moist from various fluids beneath the gums, they stick to the infected sites around your teeth. The moisture causes the release of the antibiotic minocycline, which can then access the bacteria in the intricate sites around your teeth, including the sites that are difficult to reach with other methods of treatment. The different sizes of the microspheres enable the medication to be continually released and fight the infection for at least 21 days. This helps control periodontitis for at least 12 months when used with SRP. 

Arestin is administered quickly and easily. Application is comfortable and no anesthesia is needed. Arestin does not require bandages and won’t leak or fall out or leave anything to be removed by your dentist.

Effective Clinical Trials for Arestin®

The clinical trials for Arestin® (minocycline HCl 1 mg) microspheres were large and well controlled. These studies were conducted at 22 universities and dental schools across the United States in more than 920 patients with adult periodontitis.

In these clinical trials, patients treated with Arestin plus scaling and root planing (SRP) had significantly reduced pocket depth compared to those treated with SRP alone. Pocket depth is a measurement that is used to diagnose and monitor the severity of periodontal disease. Pockets are formed around teeth when supporting tissue and bone is destroyed. Because the severity of periodontal disease is measured in part by the depth of pockets, a desired outcome in periodontal disease treatment is the reduction of pocket depth. In addition, clinical trials showed that 25 percent more patients treated with a combined therapy of Arestin plus SRP as compared to SRP treatment alone, reduced their pocket depth below 5mm, restoring their dental health to a point that can be more easily maintained.

The trials also showed that Arestin used with SRP was particularly effective in patients with cardiovascular disease and patients who smoke. Arestin was also effective in more difficult to treat teeth such as molars and in challenging to treat sites that occur between tooth roots know as furcations. Typically, molar teeth and their furcation sites in particular are hard to clean with the scaling and root planing procedure because of their shape and location in the mouth. Arestin is easy to apply, allowing dentists to reach these harder to treat sites and because Arestin is so adhesive, the antibiotic remains in these difficult to treat areas and kills the infection for a long period of time. Arestin can be administered quickly right after scaling and root planing, which allows patients to address all of their oral health needs in one brief visit.

In addition, studies show that there is a possible link between periodontal infection and cardiovascular disease, diabetes, osteoporosis and increased incidence of pre-term, low-birth weight babies. These added risks makes early diagnosis and treatment of periodontal disease even more important.

Tips After Treatment

Following treatment for periodontal disease using a combination of Arestin® and scaling and root planing (SRP), you should continue to take care of your gums and mouth by practicing good oral hygiene, brushing three times a day and flossing regularly. After treatment, avoid eating hard, crunchy, or sticky foods for one week. You can resume your normal oral hygiene routine 12 hours after treatment. To maximize the results of your treatment, speak to your dentist and follow these recommendations.

How do I get the best results from my treatment with Arestin?

To achieve the best results, follow the instructions given by your dental professional. You’ll also find these important guidelines useful: 

  • Avoid touching treated areas.
    Wait 12 hours after your treatment before brushing teeth. 
  • Wait 10 days before using floss, toothpicks, or other devices designed to clean between teeth.
    Avoid foods for 1 week that could hurt your gums. 
  • Gum disease can recur and needs to be checked regularly. Be sure to return for your follow-up appointments. 
  • Periodontitis is a chronic disease and needs to be checked regularly. Be sure to return for your follow-up appointments.